NERVOUS REGULATION OF PANCREATIC SECRETION
Pancreatic nervous regulation can only be extrinsic and intrinsic. These two opposing excitations collaborate, depending on their locations and their functions, to promote pancreatic secretion.
1-Nervous Stimulation.
Extrinsic and Intrinsic neural factors collaborate, depending on their locations and functions, to help pancreatic secretion.
2-Extrinsic Innervation.
Five pancreatic extrinsic neural input compose autonomic branches: two efferent pathways — parasympathetic and sympathetic; two afferent pathways, the vagal, the spinal, and the entero-pancreatic axis. If the primary parasympathetic neurons project exclusively to intrinsic ganglia, the other extrinsic branches on the other hand branch to pancreatic structures directly.
Afferent fibers ease connections of the pancreas to the central nervous system, which pass mainly through the splanchnic nerves. Afferent fibers are of two kinds:
-Cholinergic fibers extend through the posterior vagus to the celiac plexus, and are distributed on contact to the pancreas via the superior mesenteric and celiac pedicles.
-The adrenergic fibers, coming from a zone located between the 5 and the 10 dorsal segment, find their direction towards the pancreas by the great and the lesser splanchnic where the majority make synapses with the post-ganglionic fibers. These reach the pancreas, to mix closely with the cholinergic fibers of the peri-arterial plexus.
3-Intrinsic Innervation.
The intrinsic pancreatic innervation is a network of pancreatic neurons that cluster to form pancreatic ganglia and send unmyelinated projections to their targets in the endocrine and exocrine pancreas. Ganglia dispersed into the pancreatic islets, the exocrine acini and the ductal system. Pauci-cellular clusters forming ganglia to be disseminated in the parenchymal. Nerve endings reach acini, islets, vessels and ducts.
